Publications

Peer-Reviewed Articles

21. M. Taylor-Williams, T. W. Sawyer, R. Tao, D. Waterhouse, J. Yoon, S. E. Bohndiek. Design and Classification of Multispectral Filter Arrays for Cancer Detection in the Oesophagus and Colon. App. Opt. (2022). [In Preparation]

20. M. Taylor-Williams, S. Mead, T. Sawyer, L. Hacker, C. Williams, and S. Bohndiek. Oxygenation imaging of nailfold capillaries using multispectral LED illumination J. Biomed. Opt. (2022). [In Preparation]

19. T. W. Sawyer, G. V. Hutchens, C. C. Howard, P. S. Rice, D. G. Besselsen, M. Slayton, J. K. Barton. Multiphoton microscopy assessment of healing from tendon laceration and microthermal coagula. L. Surg. Med. (2022). [In Preparation]

18. S. Duan, T. W. Sawyer, R. Sontz, B. Wieland, A. Diaz, J. L. Merchant. Men1 Deletion Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming. Cell. Mol. Gastro. Hepatol. (2022). [In Revision] Preprint available at https://doi.org/10.1101/2022.02.10.479845

17. T. Sawyer, M. Taylor-Williams, R. Tao, R. Xia, C. Williams, and S. Bohndiek. Opti-MSFA: A toolbox for generalized design and optimization of multispectral filter arrays. Opt. Exp. 30(5), 7591-7611(2022).

16. D. Schwartz, T. Sawyer, N. Thurston, J. Barton, and G. Ditzler. Ovarian Cancer Detection Using Optical Coherence Tomography and Deep Neural Networks. Neural. Comput. Appl. 26 (2022).

15. K. Kiekens, D. Vega, H. Thurgood, D. Galvez, D. McGregor, T. Sawyer, and J. Barton. Effect of an added mass on the vibrational characteristics for raster scanning of a cantilevered optical fiber. ASME J. Med. Diagost. 4(2), 021007 (2021).

14. D. M. Sawyer, T. Sawyer, N. Eshghi, and P. Kuo. Pilot Study: Texture analysis of PET imaging demonstrates changes in 18F-FDG uptake of the brain after prophylactic cranial irradiation. J. Nuc. Med. Tech. 48(4), (2020).

13. C. Fitzpatrick, A. Wilson, T. Sawyer, T. Wilkinson, S. Bohndiek, and G. Gordon. Robustness to misalignment of low-cost, compact wide-field quantitative phase imaging architectures. OSA Cont. 3(10), 2660-2679 (2020).

12. D. Vega, T. Sawyer, N. Pham, and J. Barton. Use of embedded and patterned dichroic surfaces with optical power to enable multiple optical paths in micro-endoscope systems. App. Opt. 59(22), G71-G78 (2020).

11. T. Sawyer, J. Koevary, C. Howard, O. Austin, P. Rice, G. Hutchens, S. Chambers, D. Connolly, and J. Barton. Fluorescence and Multiphoton Imaging For Characterization of a Model of Post-Menopausal, Spontaneous Ovarian Cancer. L. Surg. Med. 52(10), 993-1009 (2020).

10. R. Blackman, D. Fischer, C. Jurgenson, D. Sawyer, T. McCracken, A. Szymkowiak, R. Petersburg, J. Ong, J. Brewer, L. Zhao, C. Leet, L. Buchhave, R. Tronsgaard, J. Llama, T. Sawyer, M. Shao, R. Trahan, B. Nemati, M. Genoni, G. Pariana, M. Riva, P. Fournier, R. Pawluczyk, A. Davis, and S. Cabot. Performance Verification of the Extreme Precision Spectrograph. Astron. J. 153(9), (2020).

9. G. Gordon, J. Joseph, M. Alcolea, T. Sawyer, C. Williams, C. Fitzpatrick, P. Jones, M. di Pietro R. Fitzgerald, T. Wilkenson, S. Bohndiek. Quantitative phase and polarisation imaging through an optical fibre applied to detection of early esophageal tumourigenesis. J. Biomed. Opt. 24(12), 126004 (2019).

8. T. Sawyer, J. Koevary, P. Rice, C. Howard, O. Austin, D. Connolly, Q. Cai, and J. Barton. Quantification of multiphoton and fluorescence images of reproductive tissues from a mouse ovarian cancer model shows promise for early disease detection. J. Biomed. Opt. 24(9), 096010 (2019).

7. G. Gordon, J. Joseph, T. Sawyer, A. Macfaden, C. Williams, T. Wilkinson, and S. Bohndiek. Full-field quantitative phase and polarisation-resolved imaging through a flexible fibre bundle. Opt. Exp. 27(17), 23929-47 (2019).

6. T. Sawyer, P. Rice, D. Sawyer, J. Koevary, and J. Barton. Evaluation of segmentation algorithms for optical coherence tomography images of the ovaries. J. Med. Imag. 6(1), 014002 (2019).

5. T. Sawyer, S. Chandra, P. Rice, J. Koevary, and J. Barton. Three-dimensional texture analysis for optical coherence tomography images of ovarian tissue. Phys. Med. Biol. 63(23), 235020 (2018).

4. T. Sawyer. Alignment of sensor arrays in optical instruments using a geometric approach. App. Opt. 57(4), 794-801 (2018).

3. T. Sawyer, K. Hawkins, and M. Damento. Using confidence intervals to evaluate the focus alignment of spectrograph detector arrays. App. Opt. 56(18), 5295-5300 (2017).

2. T. Sawyer, R. Petersburg, and S. Bohndiek. Tolerancing the alignment of large-core optical fibers, fiber bundles and light guides using a Fourier approach. App. Opt. 56(12), 3303-10 (2017).

1. T. Sawyer, A. Siri Luthman, and S. Bohndiek. Evaluation of illumination systems for biomedical hyperspectral imaging. J. Opt. 19(4), 045301 (2017).

Conference Proceedings / Abstracts

29. S. Sheriff, S. Duan, A. Diaz, T. Sawyer, J. L. Merchant. Mutations in MEN1 Gene Alter Menin Protein in Human Gastrinoma. DDW 2022

28. T. Knapp, S. Duan, J. L. Merchant, T. Sawyer. Characterizing the optical fingerprint of duodenal gastrinoma using quantitative multiphoton autofluorescence microscopy. DDW 2022

27. N. Daigle, H. Song, R. Sontz, J. L. Merchant, T. Sawyer. Demonstrating whole-organ lineage tracing of fluorescent markers in intestinal stem cells using wide-field fluorescence imaging in a Zfp148CreERT2 mouse model. DDW 2022.

26. S. Duan, T. Sawyer, R. Sontz, B. Wieland, A. Diaz, J. L. Merchant. GFAP Directed Inactivation of MEN1 Promotes Neuroendocrine Differentiation by Exploiting Glial Cell Plasticity. DDW 2022

25.  R. Carlson, C. Comrie, J. Bonaventura, E. Hutchinson, T. Sawyer Backscattering Mueller Matrix polarimetry shows promise for validation of diffusion MRI microstructural features in thick tissue specimens. ISMRM 2022.

24. H. Shir, J. Montague, D. Galvez, T. W. Sawyer, V. Nfonsam, J. K. Barton. Analysis of Quantitative Second Harmonic Generation Measurements to Distinguish Colon Cancer. L. Surg. Med. 54(S34), S1-S112 (2022).

23. S. Duan, R. Sontz, J. L. Merchant, T. Sawyer. Measuring variations in optical imaging markers in a glial cell-directed mouse model of human MEN1 syndrome. Proc SPIE 11972 (2022).

22. C. Williams, T. Sawyer, S. Bohndiek. A biomedical multispectral image sensor. Proc SPIE 11943 (2022).

21. N. Lima, T. Sawyer. Design and validation of a high-resolution multispectral fluorescence imaging system for characterizing tissue fluorescence and reflectance properties. Proc SPIE 11944 (2022).

20. J. Bonaventura, T. Knapp, J. Koshel, T. Sawyer. Smartphone spectroscopy for melanoma detection. Proc SPIE 11950 (2022).

19. B. Slomka, S. Duan, R. Sontz, T. Sawyer. Multi-band fluorescence imaging and cell collection device for in vivo tumor characterization and growth assessment in xenograft mouse models. Proc SPIE 11964 (2022).

18. T. Knapp, N. Lima, S. Duan, J. L. Merchant, T. Sawyer. Evaluation of tile artifact correction methods for multiphoton microscopy mosaics of whole-slide tissue sections. Proc SPIE 11966 (2022).

17. J. Montague, H. Shir, T. Sawyer, J. Barton. Feasibility of non-imaging, random-sampling second harmonic generation measurements to distinguish colon cancer. Proc SPIE 11972 (2022).

16. T. Sawyer, E. Salcin, A. Diaz, and J .Friedman. Using principle component analysis to estimate geometric parameters from point cloud LIDAR data. Proc SPIE 1170403 (2021).

15. E. Salcin, T. Sawyer, A. Diaz, and J. Friedman. Extraction of precise object orientation and position from LIDAR data using maximum-likelihood methods. SPIE Defense and Commercial Sensing (2021).

14. T. Sawyer, and J. Barton. Enabling high-throughput autofluorescent spectroscopy of biomarkers with liquid crystal polarization gratings. Proc SPIE 11647 (2021).

13. M. Taylor-Williams, S. Mead, T. Sawyer, C. Williams, M. Berks, A. Murray, and S. Bohndiek. A low-cost LED-based multispectral capillaroscopy system for oximetry of the nailfold. Proc. SPIE 11651 (2021).

12.S. Santaniello, P. Rice, T. Sawyer, and J. Barton. Multispectral fluorescence imaging of murine ovarian tissue for the characterization and classification of early-stage ovarian cancer. Proc. SPIE 11655 (2021).

11. T. Sawyer, and J. Barton. Liquid Crystal Polarization Grating Spectroscopy for Measuring Tissue Autofluorescence. L. Surg. Med.  52(S32), S11-S82(2020).

10. J. Yoon, G. Gordon, T. Sawyer, and S. Bohndiek. Development of a clinical multimodal imaging system for rapid characterisation of intrinsic optical properties of freshly excised tissues. Proc. SPIE 11232 (2020).

9. T. Sawyer, C. Williams, and S. Bohndiek. Spectral Band Selection and Tolerancing for Multispectral Filter Arrays. OSA Technical Digest (2019).

8. T. Sawyer, J. Koevary, P. Rice, and J. Barton. In vivo optical coherence tomography of a mouse model of spontaneous ovarian cancer. Proc. SPIE 11073 (2019).

7. J. Barton, J. Koevary, P. S. Rice, and T. Sawyer. Endogenous and exogenous contrast mechanisms for detection of ovarian cancer. OSA Technical Digest (2019).

6. T. Sawyer, J. Koevary, P. Rice, and J. Barton. Fluorescence and Multiphoton Imaging of a Mouse Model of Spontaneous Ovarian Cancer. OSA Technical Digest (2019).

5. T. Sawyer, P. Rice, J. Koevary, D. Connolly, Q. Cai, and J. Barton. In vivo multiphoton imaging of an ovarian cancer mouse model. Proc. SPIE 10856 (2019).

4. T. Sawyer, P. Rice, D. Sawyer, J. Koevary, and J. Barton. Evaluation of segmentation algorithms for optical coherence tomography images of ovarian tissue. Proc. SPIE 10472 (2018).

3. C. Fitzpatrick, T. Sawyer, and S. Bohndiek. Wide-field phase imaging for the endoscopic detection of dysplasia and early-stage esophageal cancer. Proc. SPIE 10470 (2018).

2. T. Sawyer and S. Bohndiek. Towards a software framework for maximizing the resolution of biomedical hyperspectral imaging. European Conferences on Biomedical Optics. Proc. SPIE 10412 (2017).

1. T. Sawyer, A. Luthman, and S. Bohndiek. Evaluation of illumination systems for wide-field hyperspectral imaging in biomedical applications. Proc. SPIE 9711 (2017).

Posters

14. T. Knapp, S. Duan, J. L. Merchant, T. Sawyer. Characterizing the optical fingerprint of duodenal gastrinoma using quantitative multiphoton autofluorescence microscopy. [Accepted for DDW 2022]

13. N. Daigle, H. Song, R. Sontz, J. L. Merchant, T. Sawyer. Demonstrating whole-organ lineage tracing of fluorescent markers in intestinal stem cells using wide-field fluorescence imaging in a Zfp148CreERT2 mouse model. [Accepted for DDW 2022]

12.  R. Carlson, C. Comrie, J. Bonaventura, E. Hutchinson, T. Sawyer Backscattering Mueller Matrix polarimetry shows promise for validation of diffusion MRI microstructural features in thick tissue specimens. ISMRM 2022 (May 9, 2022).

11. M. Aitken, J. Montague, T. Sawyer, J. Barton. Tissue Compression Design in Optical Coherence Elastography for Early Detection of Cancer. University of Arizona 10th Annual Biomedical Engineering Expo (March 24, 2022).

10. H. Shir, J. Montague, T. Sawyer, J. Barton. Non-Linear Analysis of Collagen in Murine Ovarian Samples Using Second Harmonic Generation. University of Arizona 10th Annual Biomedical Engineering Expo (March 24, 2022).

9.  R. Carlson, C. Comrie, J. Bonaventura, E. Hutchinson, T. Sawyer Backscattering Mueller Matrix polarimetry shows promise for validation of diffusion MRI microstructural features in thick tissue specimens. [Accepted for ISMRM 2022]

8. K. Morara, R. Carlson, C. Comrie, E. Hutchinson, T. Sawyer. Advanced polarization imaging techniques for microstructural validation of diffusion MRI. University of Arizona 10th Annual Biomedical Engineering Expo (March 24, 2022).

7. J. Setiadi, T. Knapp, J. Bonaventura, J. Merchant, T. Sawyer. Polarization imaging to identify disease features of gastrinoma. University of Arizona 10th Annual Biomedical Engineering Expo (March 24, 2022). [First place undergraduate poster]

6. T. Knapp, S. Duan, J. Merchant, T. Sawyer. Characterizing the optical fingerprint of duodenal gastrinoma using quantitative multiphoton autofluorescence microscopy. University of Arizona 10th Annual Biomedical Engineering Expo (March 24, 2022). [First place graduate poster]

5. S. Duan, T. Sawyer, R. Sontz, B. Wieland, A. Diaz, J. L. Merchant. GFAP-Directed Inactivation of MEN1 Promotes Neuroendocrine Differentiation by Exploiting Glial Cell Plasticity. University of Arizona Cancer Center Annual Scientific Retreat (November 20, 2021).

4. H. Shir, J. Montague, T. Sawyer, J. Barton. Non-Linear Analysis of Collagen in Murine Ovarian Samples Using Second Harmonic Generation. University of Arizona Cancer Center Annual Scientific Retreat (November 20, 2021).

3. J. Montague, H. Shir, T. Sawyer, D. Galvez, J. Barton. Quantitative Second Harmonic Imaging of Colon Cancer. University of Arizona Cancer Center, Cancer Research: Present and Future (August 4, 2021).

2. H. Shir, J. Montague, T. Sawyer, J. Barton. Non-Linear Analysis of Collagen in Murine Ovarian Samples Using Second Harmonic Generation. University of Arizona Cancer Center, Cancer Research: Present and Future (August 4, 2021).

1. J. Bonaventura, T. Knapp, J. Koshel, T. Sawyer. Melanoma Screening with Smartphone Spectroscopy. Cancer Research Past and Future. University of Arizona Cancer Center. (August 4 2021). 

Patents

4. B. Slomka, T. Sawyer. “Miniature Multispectral Fluorescence Imaging and Cell Collection Probe.” Patent US 63/266,791 (Filed January 14, 2022).

3. J. Bonaventura, T. Knapp, J. Koshel, T. Sawyer. “Self-Calibrating Spectrometer With Adjustable Spectral Resolution and Spectral Range.” Patent US 63/243,038 Pending (Filed September 10 2021).

2. J. Bonaventura, T. Knapp, J. Koshel, T. Sawyer. “Advanced Spectroscopy using a Camera of a Personal Device.” Patent US 63/243,034 Pending (Filed September 10 2021).

1. S. Bohndiek, D. Waterhouse, T. Sawyer. “Determination of spectral filters for spectral imaging.” Patent GB2104680.0 (Filed March 31 2021).