Research

Neuroendocrine Tumors

We are interested in studying gastrointestinal neuroendocrine tumors, specifically gastrin-secreting duodenal tumors called gastrinomas. We are applying multiphoton and fluorescence imaging for advancing basic understanding cell signaling and metabolic assessment, and also with the aim of developing improved surgical localization techniques. We also are developing an animal model of gastrinoma to assess imaging techniques for surgical localization and minimally-invasive detection.

Multispectral and Polarization-sensitive Imaging for Esophageal Cancer Detection

One major area of research in our laboratory is detection of esophageal cancer, both adenocarcinoma and squamous cell carcinoma. We aim to implement multispectral and polarization imaging for early detection of these diseases. We are developing chip-on-tip endoscopes with custom filtered spectrally sensor arrays that select the more diagnostically relevant spectral components for targeted disease diagnostics.

Smartphone Spectroscopy for Point-of-Care Melanoma Detection

We have partnered with Tech Launch Arizona to develop a fully smartphone-based diagnostic system for melanoma detection using spectroscopy. The system incorporates a custom optical design that couples to a commercial smartphone. Integrating advanced analytic techniques, the acquired data can be used for automatic assessment and risk prediction for a tissue sample.

Developing Validation Methods for Magnetic Resonance Imaging using Polarization Imaging and Optical Coherence Tomography

A major aim in our lab is to implement optical imaging for the validation of diffusion MRI techniques. We aim to implement optical coherence tomography and polarization imaging for assessment of cellular structure, anisotropy, and plaque content in brain tissues.