{"id":1947,"date":"2024-11-20T16:32:16","date_gmt":"2024-11-20T16:32:16","guid":{"rendered":"https:\/\/live-optics-wp.pantheonsite.io\/jsu\/?p=1947"},"modified":"2024-11-20T16:32:18","modified_gmt":"2024-11-20T16:32:18","slug":"paper-published-in-pnas","status":"publish","type":"post","link":"https:\/\/wp.optics.arizona.edu\/jsu\/paper-published-in-pnas\/","title":{"rendered":"Paper published in PNAS"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Glad to share our latest work in <em>PNAS<\/em><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2409987121\">Agonist activation to open the G\u03b1 subunit of the GPCR\u2013G protein precoupled complex defines functional agonist activation of TAS2R5 | PNAS<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Our study reveals the underlying molecular mechanisms of ligand-induced activation in the human bitter taste receptor TAS2R5. Despite similar binding energies, significant variations in agonist potencies were observed. Using live cell-based assays, optical resonators, and molecular dynamics simulations, we found that the activation energy of the opening of the G\u03b1 subunit for GDP\u2013GTP exchange, rather than binding affinity alone, correlates highly with agonist potency. This finding refines our understanding of G protein-coupled receptor (GPCR) activation, paving the way for the rational design of new therapeutic agents targeting these receptors.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Glad to share our latest work in PNAS Agonist activation to open the G\u03b1 subunit of the GPCR\u2013G protein precoupled complex defines functional agonist activation of TAS2R5 | PNAS Our study reveals the underlying molecular mechanisms of ligand-induced activation in the human bitter taste receptor TAS2R5. Despite similar binding energies, significant variations in agonist potencies were observed. Using live cell-based<\/p>\n","protected":false},"author":36,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-1947","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/wp.optics.arizona.edu\/jsu\/wp-json\/wp\/v2\/posts\/1947","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.optics.arizona.edu\/jsu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wp.optics.arizona.edu\/jsu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wp.optics.arizona.edu\/jsu\/wp-json\/wp\/v2\/users\/36"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.optics.arizona.edu\/jsu\/wp-json\/wp\/v2\/comments?post=1947"}],"version-history":[{"count":1,"href":"https:\/\/wp.optics.arizona.edu\/jsu\/wp-json\/wp\/v2\/posts\/1947\/revisions"}],"predecessor-version":[{"id":1948,"href":"https:\/\/wp.optics.arizona.edu\/jsu\/wp-json\/wp\/v2\/posts\/1947\/revisions\/1948"}],"wp:attachment":[{"href":"https:\/\/wp.optics.arizona.edu\/jsu\/wp-json\/wp\/v2\/media?parent=1947"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wp.optics.arizona.edu\/jsu\/wp-json\/wp\/v2\/categories?post=1947"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wp.optics.arizona.edu\/jsu\/wp-json\/wp\/v2\/tags?post=1947"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}