Front Cover of Chemical Communications

 

Labels like fluorescent tags are powerful but often perturb the system. Our work highlights FLOWER, a technique that eliminates this need by using frequency-locked optical microcavities for ultra-sensitive, stable, and portable label-free sensing.

I’m happy to share that our Feature Article is featured on the front cover of Chemical Communications as part of the Pioneering Investigators collection.

 

 

NIH Quantum Sensing Technology Challenge

Thrilled to share that our team under the leadership of Pri Narang (UCLA) has been selected as a Stage 1 Winner of the NIH Quantum Sensing Technology Challenge.

This recognition highlights the potential of quantum-enabled technologies to transform biomedical research. We’re looking forward to competing in the second stage.

Grateful to NIH for launching this forward-looking initiative.

Read the announcement here: Challenge.gov

Chemical Communications 2025 Pioneering Investigators Collection

Glad to share our latest article which is part of Chemical Communications’ 2025 Pioneering collection. The article focuses on my past and current research and puts it in perspective. I appreciate all my lab members, collaborators, and sponsors who made this possible:

FLOWER: A Frequency-Locked Optical Whispering Evanescent Resonator for Label-Free Molecular Detection – Chemical Communications (RSC Publishing)

Paper published in PNAS

Glad to share our latest work in PNAS

Agonist activation to open the Gα subunit of the GPCR–G protein precoupled complex defines functional agonist activation of TAS2R5 | PNAS

Our study reveals the underlying molecular mechanisms of ligand-induced activation in the human bitter taste receptor TAS2R5. Despite similar binding energies, significant variations in agonist potencies were observed. Using live cell-based assays, optical resonators, and molecular dynamics simulations, we found that the activation energy of the opening of the Gα subunit for GDP–GTP exchange, rather than binding affinity alone, correlates highly with agonist potency. This finding refines our understanding of G protein-coupled receptor (GPCR) activation, paving the way for the rational design of new therapeutic agents targeting these receptors.

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