Our lastest work on label-free characterization of GPCR interactions at extremely low (zeptomolar) concentrations has been published in Nature Communications. We thank an NIGMS R35 grant and the Gordon and Betty Moore Foundation for support.
I am happy to share our first paper on the early diagnosis and screening of Alzheimer’s disease.
https://www.nature.com/articles/s44328-024-00009-8
In this study, we utilize the ultra-sensitivity of FLOWER (frequency-locked optical whispering evanescent resonator) to quantify levels of the Alzheimer’s disease (AD) biomarker Aβ42 in post-mortem cerebrospinal fluid (CSF) from control, mild cognitive impairment (MCI), and AD participants. We demonstrate FLOWER’s capability to effectively screen CSF samples for AD diagnosis. Measuring Aβ levels can facilitate early AD diagnosis and support drug studies and efforts to delay dementia. FLOWER was able to distinguish healthy cognitively unimpaired participants from those with MCI and AD, marking an important advancement in early diagnosis.
We would like to thank an NIGMS R35 grant, an NIA NIH R03 grant, and the Arizona Alzheimer’s Consortium for their generous support, which made this investigation possible.
Our work on combining microtoroid optical resonators with photothermal microscopy to detect single 5 nm quantum dots with a signal-to-noise ratio > 10^4 without the use of labels has been published in Light: Science & Applications. We thank an NIGMS R35 grant and the Gordon & Betty Moore foundation for support. We anticipate our work will have applications in a variety of fields including the biological sciences, nanotechnology, materials science, chemistry, and medicine.